![]() Renal autoregulation is a crucial aspect of microcirculation that allows the kidney to maintain a stable renal blood flow and glomerular filtration rate despite the variations in blood pressure. In investigating the influence of hypertension on the kidney, accumulating evidence suggests that microcirculatory hemodynamic changes occur in the pathogenesis of hypertension 1. Similar content being viewed by othersĬhronic kidney disease, mainly driven by diabetes and hypertension, affects about 10% of the global population and is defined by the functional and structural degradation of the kidney, impairing its ability to filter the blood. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure.
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